Skip Global navigation and goto content

Monkeypox Vaccine Information

Department of Health in Orange County Call Center

  •  407-723-5004
    8:00AM - 5:00PM, Monday through Friday

    Mailing Address

    6101 Lake Ellenor Drive  

    Orlando, Florida 32809

Book an Appointment

FREE Smallpox/Monkeypox Vaccine (JYNNEOS)


The Florida Department of Health in Orange County (DOH-Orange) is offering the Smallpox/Monkeypox Vaccine – JYNNEOS by appointment only to those people with certain risk factors who are more likely to be exposed to monkeypox.

These groups include:

  • Known contacts who are identified by public health via case investigation, contact tracing, and risk exposure assessments.
  • Laboratory workers who perform diagnostic testing for monkeypox and members of designated health care worker response teams designated by appropriate public health authorities.
  • Those who identify as gay or bisexual men, or other men who have sex with men. 

Please visit the CDC website for more information about Smallpox/Monkeypox JYNNEOS Vaccine.

Please visit the CDC website for more information about monkeypox signs and symptoms, how it spreads, and what to do if you are sick.

If you are currently experiencing symptoms of Monkeypox, we will not vaccinate you. We encourage you to get tested first to ensure that you are not already infected. Symptoms of Monkeypox include:

  • Fever
  • Headache
  • Muscle aches and backache
  • Swollen lymph nodes
  • Chills
  • A rash that can look like pimples or blisters that appears on the face, inside the mouth, and on other parts of the body like the hands, feet, chest, genital and anal area.  

Hepatitis A (Havrix) and Meningococcal disease vaccine (Menveo) is also being offered to those at high risk at this time and may be received during the same appointment.

Appointments are filling up fast so please check back often for more availability. Appointments are only available online. 

Please be aware, your answers to the exposure assessment questions will be reviewed and your appointment may be canceled, if no high-risk exposure indicated for prophylaxis (vaccine) has been determined.

No walk-ins accepted. If there are no appointments available at this time, please check this website frequently.  DOH-Orange will offer new appointments as additional vaccine becomes available.